GeneDiseaseValidityProposition

Warning

This data class is at a draft maturity level and may change significantly in future releases. Maturity levels are described in the GKS Maturity Model.

Computational Definition

A proposition that variants affecting a particular Gene are valid for evaluation as causal for some Condition using appropriate variant classification criteria, given a specific mode of inheritance.

Information Model

Some GeneDiseaseValidityProposition attributes are inherited from Proposition.

Field

Flags

Type

Limits

Description

id

string

0..1

The ‘logical’ identifier of the Entity in the system of record, e.g. a UUID. This ‘id’ is unique within a given system, but may or may not be globally unique outside the system. It is used within a system to reference an object from another.

name

string

0..1

A primary name for the entity.

description

string

0..1

A free-text description of the Entity.

aliases

string

0..m

Alternative name(s) for the Entity.

extensions

Extension

0..m

A list of extensions to the Entity, that allow for capture of information not directly supported by elements defined in the model.

type

string

1..1

MUST be “GeneDiseaseValidityProposition”.

subjectGene

Mappable Concept | iriReference

1..1

The Entity or concept about which the Proposition is made.

predicate

string

1..1

MUST be “variantsInGeneCausalFor”.

objectCondition

Mappable Concept | iriReference

1..1

An Entity or concept that is related to the subject of a Proposition via its predicate.

modeOfInheritanceQualifier

Mappable Concept | iriReference

0..1